The most important anti-inflammatory actions of St. John’s wort oil on damaged and inflamed skin, and mucous membrane attributed mainly to acylphloroglucinol derivatives hyperforin which is the main ingredient of lipophilic plant Hypericum perforatum. In a new scientific work for the first time is reported that hyperforin as well as extracts of H. perforatum , strongly suppress 5 – lipoxygenase ( 5 – LO ) and cyclooxygenase ( COX ) -1 , the key enzyme in the formation of proinflammatory eicosanoids from arachidonic acid ( AA ). This mechanism could explain the strong anti-inflammatory activity on products of St John’s wort.
Hyperforin is also a powerful antibacterial agent active against Staphylococcus aureus and other bacteria.
The main dianthrone compounds from St. John’s wort are hypericin and pseudohipericin and these are the components that exhibit antiviral activity. Hypericin , and to a lesser extent pseudohipericin act against viruses by inactivating viruses mature and inhibit proper reproduction of the virus -infected cells. They are effective against viruses with a membrane (those viral cells surrounded with lipid membranes) , including herpes simplex types 1 and 2 , and some others. However the hypericin has potential activity against retroviruses, including virus (HIV) which aroused the greatest possible interest. Although there is a lot of research, we can say that hypericin from St. John’s wort is showing promise as a potential cure for HIV retrovirus that causes AIDS.
Carotenoids, epoxy xanthophylls, help heal wounds, cuts, burns of the skin , as well as restoring the vaginal mucosa damaged due to various infectious processes , or conditions that cause vaginal dryness (menopause , hormonal imbalance different states ) .
The conditions which lead to increased vaginal discharge, astringent properties of catechin tannins from St. John’s wort appear to have a beneficial effect. St. John’s Wort oil is generally the damaged skin and vaginal mucosa acts as a lubricant.
– Inflammation of the skin caused by cuts and burns , and wounds of various origins , as well as those that arise after surgery .
– Changes in cervical mucosa, caused by inflammation.
– Degenerative changes in the cervical and vaginal mucosa may occur after therapy radiation.
– Changes in the vaginal lining caused due to vaginal dryness different origin or due to hormonal imbalance in menopause.
For topical ( external use ) St. John’s wort oil on the open surface of the skin is necessary to protect these areas from direct sunlight because of the well-known phototoxic effects that can occur when these areas are exposed to the sun .